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History of 'Role of Moringa oleifera extract in the regulation of thyroid hormone status in adult male and female rats'

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Role of Moringa oleifera extract in the regulation of thyroid hormone status in adult male and female rats

Author(s): Tahiliani P, A. Kar
Published in: Pharmacological Research.   Aug 23, 1999
31 3 pp 319-323

A study was performed in order to determine the effects of Moringa oleifera leaf extracts on thyroidal hormones. Groups of rats were were orally given either distilled water, the control, or an equal amount of the extract for 10 days. Results showed decreases in the main thyroidal hormone (T3) and increases in its prohormone (T4), but results were only significant in female rats. A proposed explanation is that females are nearly five times as susceptible to thyroid imbalances, but also because of this, the study was repeated with female mice only and the doses changed. The higher dosage also showed the same decrease/increase in hormones, but did not significantly alter other chemical levels being monitored to determine safety of the drug, so the lower dosage was proclaimed safer to use for the treatment of hyperthyroidism.


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Author(s): Tahiliani P, A. Kar
Published in: Pharmacological Research.   Aug 23, 1999
31 3 pp 319-323
http://mail.treesforlife.org:8083/moringa_articles/Tahiliani_1999_PharmacolRes_MoringaThyroid.pdf

A study was performed in order to determine the effects of Moringa oleifera leaf extracts on thyroidal hormones. Groups of rats were were orally given either distilled water, the control, or an equal amount of the extract for 10 days. Results showed decreases in the main thyroidal hormone (T3) and increases in its prohormone (T4), but results were only significant in female rats. A proposed explanation is that females are nearly five times as susceptible to thyroid imbalances, but also because of this, the study was repeated with female mice only and the doses changed. The higher dosage also showed the same decrease/increase in hormones, but did not significantly alter other chemical levels being monitored to determine safety of the drug, so the lower dosage was proclaimed safer to use for the treatment of hyperthyroidism.


Set to this revision Revision: Thu, 16 Aug 2007 11:23:10 +0000



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